#Stereology visiopharm vis serial number#
#Stereology visiopharm vis software#

A more recent study demonstrated that testicular vasculature might also be important for germ cell defects found in Klinefelter syndrome 11. Reduction of blood flow due to decreased diameter of microvascular lumen in testes was suggested as a possible cause for degenerative changes of germ cells, oligospermia in humans 8 and age-dependent disturbances of spermatogenesis 9, 10. In man, early investigations of undescended testes linked reduced blood perfusion to atrophy and hypoplasia of the organ 7. The appearance of a regular testicular microvasculature was described previously for different species 3, 4, 5, 6. Focal tubular sclerosis was also reported in association with atherosclerotic lesions of interstitial testicular vessels 2.ДЇor a given organ, a healthy capillary vascular bed with its regular architecture is the prerequisite for adequate perfusion and function of this organ. Thus, this study calls for specific treatment of male infertility induced by microvascular damage through hypercholesterolemia and atherosclerosis.Дecline of androgen blood levels, dysfunctional sperm, and histologic changes, such as focal atrophy of seminiferous tubules and reduction of tubular diameter, are considered signs of male hypogonadism 1.

Our data suggest reduced testosterone levels in this atherosclerosis model might be explained by both, rarefication of the capillary network and reduced Leydig cell number and size. Reduced litter size of the KO mice suggests hypo- or infertility as a consequence of the testicular defects. These structural changes in the testis occurred on an inflammatory background revealed by qPCR. Stereological analyses of interstitial cells demonstrated significantly reduced Leydig cell numbers and size. In addition to micro-CT investigations for bigger vessels, stereology revealed a reduction of capillary length, volume and surface area suggesting capillary rarefaction as a factor for diminished testosterone. In KO mice, overall testosterone levels were reduced whereas the adrenal gland-specific corticosterone was increased excluding a general defect of steroid hormone production. We used the apolipoprotein E (ApoE)/low density lipoprotein (LDL) receptor deficient mouse model (KO) for atherosclerosis (20, 40, 60 and 87-week-old) to investigate whether Leydig cells or the capillary network are responsible for reduced serum testosterone levels previously observed in extreme ages of this model.

#Stereology visiopharm vis software#

We continuously broaden the integration possibilities for our scaleable software solution to fit the needs and volumes of any lab with seamlessly plugs into LIS/LIMS, IMS, VNA, or PACS systems already installed in the lab.The testis as a site for atherosclerotic changes has so far attracted little attention.

Along with several improvements to batch processing using queueing.

New integrations to Sectra, OME.TIFF slide format integration (for Advanced Multiplexing) and 3D connection mouse.

Sorting of images in Slide Tray based on their output variable.

Implementation of new and improved alignment model.

#Stereology visiopharm vis serial number#

More visible APP information and related APP serial number.New features and functionalities in the new software include improved usability on: OurВ digital image analysis softwareВ platform continues to evolve and improve in our efforts fighting cancer in histopathology.В The new 2018.4 version ofВ VIS Image Analysis SoftwareВ (for research use only) is ready for our new and existing customers. Visiopharm Releases Version 2018.4 of VIS Image Analysis Software вЂ“ Adding More User-Friendly Functionalities